How do 5 HT2A receptors work
Serotonin receptors [from Latin. serum = whey, Greek tonos = tension, Latin. receptor = recipient], 5-hydroxytryptamine receptors, 5-HT receptors, E. serotonin receptors, transmembrane glycoproteins, the aqueous pores of which open after binding of the monoamine neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). The receptors are classified based on the secondary messenger system they control: the 5-HT1-, 5-HT2- and 5-HT4Receptors belong to the family of G protein-coupled receptors. The 5-HT1a-, 5-HT1b-, 5-HT1d- and 5-HT4Receptors inhibit adenylate cyclase, 5-HT1c- and 5-HT2- Receptors stimulate the conversion of inositol phosphates. Depending on the post-receptor mechanism, the effect of serotonin can be inhibitory (e.g. activation of a 5-HT1Receptor on pyramidal cells of the hippocampus leads directly to the opening of potassium channels via a G protein and via the subsequent hyperpolarization to the inhibition of neuronal activity) or excitatory (activation of a 5-HT2Receptor leads to the synthesis of the messenger substance IP via the stimulation of phospholipase C3which causes the release of calcium from intracellular stores and thus leads to the contraction of the smooth muscles). The 5-HT3Receptor, on the other hand, belongs to the family of ligand-gated ion channels and is a non-selective cation channel. Of the physiologically relevant ions, sodium and potassium in particular can pass through the channel. After opening the channels, Na flows along its electrochemical gradient+ into the interior of the cell, K+ leaves it. The net result is an inward ion current, the cell is depolarized. 5-HT3Receptors are therefore excitatory. So far, they have been found in the autonomic nervous system, in sensory pain fibers and in the brain. Activation of central 5-HT3Receptors in the nucleus tractus solitarius causes vomiting.
Of the seven known serotonin receptors in vertebrates, types 1 and 2 (5-HT1 and 5-HT2) also for Mollusks be detected. At Gastropods can using methiothepin, a ligand of 5-HT1- and 5-HT2Receptor that prevents oviposition in a dose-response relationship for a limited period of time.
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