What are thiols
ThiolsThiols are sulfur analogues of alcohols with the general chemical structure R-SH. In contrast to alcohols, they hardly form hydrogen bonds and therefore have a lower boiling point. The low molecular weight representatives are volatile and have an unpleasant odor. Thiols are stronger acids than alcohols and can form salts with bases. Some active substances are thiols, for example the ACE inhibitor captopril.
synonymous: mercaptans, R-SHdefinition
Thiols are organic compounds with the general structure R-SH. They are sulfur analogues of alcohols (R-OH). R can be aliphatic or aromatic. The simplest aliphatic representative is methanethiol, the simplest aromatic is thiophenol (analogue of phenol).
Thiols are formally derived from hydrogen sulfide (H.2S) derived, in which a hydrogen atom has been replaced by a radical.nomenclature
The names of the compounds are formed with the suffix -thiol. The outdated suffix or prefix mercaptan is also common for some molecules and active ingredients. The -SH group is referred to as the sulfhydryl group.
The name thiol is derived from sulfur.Representative
- Low molecular weight thiols often have an unpleasant odor, for example like rotten eggs and putrefaction.
- Skunks make thiols.
- Due to the small difference in the electronegativity of sulfur and hydrogen, thiols are hardly polar and hardly form hydrogen bonds. Therefore the boiling points are lower than with comparable alcohols. Thiols are volatile (odor).
- For the same reason, the thiols are less soluble in water.
Thiols are stronger acids than alcohols. Your pKa is around 8 to 10:Reactions
Like the alcohols, the thiols can form esters, the so-called thioesters. Ethers with a sulfur atom are called thioethers and organic sulfides (suffix: -sulfide).
Thiols can be oxidized to disulfides:
- R1-SH + R2-SH → R1-S-S-R2
Proteins such as insulin and its derivatives can contain disulfide bridges between cysteines.In pharmacy
Some active pharmaceutical ingredients are thiols, for example the ACE inhibitors captopril or mercaptamine.
- Medicinal product information
- Specialist literature
- Chemistry textbooks
Conflicts of Interest: None / Independent. The author has no relationships with the manufacturers and is not involved in the sale of the products mentioned.
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This article was last changed on 11/18/2020.
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